I just returned from the Scorpio: Diagnostic Server Monitoring and Realtime Alerts session and saw some real impressive stuff... Adobe has essentially pulled back the covers on the internal metrics and logging to allow developers and admins more insight into performance bottlenecks and troubleshooting various problems.

Another new feature that I'm interested in is the ability to cache queries with cfqueryparam. This deficiency has bothered me for quite some time because I always try to use cfqueryparam whenever accepting any input from url or form to prevent sql injections and this prevents taking advantage of performance gains from caching frequently used queries.